袁秋华,石 鑫,梁进仁,等.铈锌共掺杂HA-GP复合物合成及抗菌性研究[J].深圳大学学报理工版,2021,38(3):280-286.[doi:10.3724/SP.J.1249.2021.03280]
YUAN Qiuhua,SHI Xin,LIANG Jinren,et al.Preparation and antibacterial properties of cerium-zinc co-doped hydroxyapatite-graphene composite[J].Journal of Shenzhen University Science and Engineering,2021,38(3):280-286.[doi:10.3724/SP.J.1249.2021.03280]
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铈锌共掺杂HA-GP复合物合成及抗菌性研究
袁秋华,石 鑫,梁进仁,万 磊,简友亮,杨 袁,李瑞龙,代小毅,吴文珊

深圳大学化学与环境工程学院,广东深圳 518060

生物材料; 锌离子; 铈离子; 羟基磷灰石; 石墨烯; 共掺杂; 水热法; 抗菌性能

Preparation and antibacterial properties of cerium-zinc co-doped hydroxyapatite-graphene composite
YUAN Qiuhua, SHI Xin, LIANG Jinren, WAN Lei, JIAN Youliang, YANG Yuan, LI Ruilong, DAI Xiaoyi, and WU Wenshan

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, Guangdong Province, P.R.China

biomaterials; Ce ion(Ce3+); Zn ion(Zn2+); hydroxyapatite; graphene; co-doping; hydrothermal method; antibacterial property

DOI: 10.3724/SP.J.1249.2021.03280

备注

铈(Ce)和锌(Zn)都是人体中常见的微量元素,Ce-Zn共掺杂的羟基磷灰石(hydroxyapatite, HA)复合材料在生物医用领域有良好的应用价值.通过一锅水热法成功合成Ce-Zn共掺杂的HA-石墨烯(graphene, GP)复合粉体材料.借助X射线衍射、傅里叶红外光谱、拉曼红外光谱、场发射扫描电子显微镜、能量色散X射线光谱和透射电子显微镜等技术对合成的复合材料进行表征分析.结果表明,通过水热法可成功制备Ce-Zn共掺杂HA-GP复合粉体材料,铈离子和锌离子成功替代部分钙离子进入HA的晶格中.由于铈离子、锌离子与钙离子半径不同,随着铈离子和锌离子掺杂摩尔分数的增加,复合材料中无定形相晶型增多,并且开始出现团聚现象; 通过抗菌性能测试,发现引入铈离子和锌离子的HA-GP复合材料的抗菌性得到较大提高,当铈离子和锌离子掺杂摩尔分数均增至10%时,Ce-Zn-HA-GP复合材料的杀菌率达到93.2%.Ce-Zn共掺杂HA-GP复合材料有良好的抗菌应用前景.
Cerium(Ce)and zinc(Zn)are common trace elements in human bodies. Ce-Zn co-doped hydroxyapatite(HA)composites has good application value in biomedical field. In this study, Ce-Zn co-doped hydroxyapatite-graphene(HA-GP)composite powders are successfully synthesized by a one-pot hydrothermal method. Then, the Ce-Zn co-doped hydroxyapatite-graphene composites are characterized by a set of techniques including X-ray diffraction(XRD), Fourier transform infrared(FTIR), Raman infrared(Raman), field emission scanning electron microscopy(FESEM), energy dispersive X-ray spectroscopy(EDX)and transmission electron microscopy(TEM). The results show that Ce and Zn ions have been successfully doped into HA lattice by replacing partial Ca ions. However, due to the difference between the radii of Ce, Zn and Ca ions, the amorphous phases in the obtained composites increase with the increase of doping ratios, and the agglomeration phenomenon begins to appear as well. The antibacterial tests show that doping of Ce and Zn ions greatly improves the antibacterial properties of the composites. The sterilization rate reaches up to 93.2% as the doping content is increased to 10%(molar ratio), which implies that Ce-Zn co-doped HA-GP composite has a good antibacterial application prospect.
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