深圳大学学报理工版

建立基于VerasonicsTM Vantage256 超声开放系统的实验平台,用声辐射力激励角膜振动,通过快速平面波成像检测A0模式兰姆波的传播,根据兰姆波的频散特性估计牛眼角膜的剪切弹性模量和剪切黏性系数.通过对牛眼角膜进行离体实验研究,评估紫外线-核黄素角膜胶原交联术(corneal collagen cross-linking, CXL)中加入戊二醛和不同紫外线照射时间的影响.结果表明,加入质量分数为0.1%的戊二醛对角膜的硬化效果较未加入的更强.加入质量分数为0.1%的戊二醛的CXL处理组,紫外线照射5、10、30和60 min对应的杨氏模量比直接CXL处理组的弹性值分别增大了148.78%、335.68%、392.59%和250.47%.

This study establishes an experimental platform based on VerasonicsTM Vantage 256 ultrasonic open system, and uses the acoustic radiation force to excite the corneal vibration and uses plane wave imaging to detect A0 mode Lamb wave. The corneal shear elastic modulus and shear viscosity are estimated based on Lamb wave dispersion characteristics. In order to validate the effectiveness of this system, two kinds of CXL treatments are introduced to treat bovine corneas, and the effect of the treatment with different reagent and UV exposure duration are evaluated. The results show that the CXL with the addition of glutaraldehyde(0.1% mass concentration)in riboflavin solution induces significantly higher increase in elasticity in comparison with those without glutaraldehyde. The elasticity of the group with glutaraldehyde after 5, 10, 30 and 60 min UVA exposure increases by 148.78%、 335.68%, 392.59% and 250.47%, respectively, in comparison with the groups without glutaraldehyde.

引言
1 方法原理
2 结果与讨论
3 结语

图1 超声实验过程中眼球与探头的关系及角膜组织振动位移信息<br/>Fig.1 Relationship between eyeball and probe, and vibration displacement information of corneal tissue during ultrasonic experiment

图1 超声实验过程中眼球与探头的关系及角膜组织振动位移信息
Fig.1 Relationship between eyeball and probe, and vibration displacement information of corneal tissue during ultrasonic experiment

表1 超声检测角膜分组标号及样本个数<br/>Table 1 Group labeling and sample numbers of bovine corneas

表1 超声检测角膜分组标号及样本个数
Table 1 Group labeling and sample numbers of bovine corneas

图2 方案1各分组对应的兰姆波速度频散曲线<br/>Fig.2 Lamb wave velocity dispersion curves of the groups in CXL scheme 1

图2 方案1各分组对应的兰姆波速度频散曲线
Fig.2 Lamb wave velocity dispersion curves of the groups in CXL scheme 1

图3 方案2各分组兰姆波速度频散曲线<br/>Fig.3 Lamb wave velocity dispersion of the groups in CXL scheme 2

图3 方案2各分组兰姆波速度频散曲线
Fig.3 Lamb wave velocity dispersion of the groups in CXL scheme 2

图4 方案1与方案2对应的各分组弹性值箱线图分布图<br/>Fig.4 Boxplots of estimated shear elasticity for all groups

图4 方案1与方案2对应的各分组弹性值箱线图分布图
Fig.4 Boxplots of estimated shear elasticity for all groups

表2 两方案角膜处理方式中的各分组黏性均值((-overx)±s)<br/>Table 2 Mean and standard deviation of shear viscosity forall groups((-overx)±s)mPa·s

表2 两方案角膜处理方式中的各分组黏性均值((-overx)±s)
Table 2 Mean and standard deviation of shear viscosity forall groups((-overx)±s)mPa·s

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备注

引言

1 方法原理

2 结果与讨论

3 结语

期刊信息

备注

引言

1 方法原理

2 结果与讨论

3 结 语

期刊信息

3 结语