[1]倪卓,杨莎,吴耿峰,等.PES-HA生物复合材料的热稳定性和生物毒性[J].深圳大学学报理工版,2017,34(3):313-318.[doi:10.3724/SP.J.1249.2017.03313]
　Ni Zhuo,Yang Sha,Wu Gengfeng,et al.Thermal stability and biotoxicity of PES-HA biocomposites[J].Journal of Shenzhen University Science and Engineering,2017,34(3):313-318.[doi:10.3724/SP.J.1249.2017.03313]
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PES-HA生物复合材料的热稳定性和生物毒性()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第34卷
期数:
2017年第3期
页码:
313-318
栏目:
化学与化工
出版日期:
2017-05-30

文章信息/Info

Title:
Thermal stability and biotoxicity of PES-HA biocomposites
文章编号:
201703014
作者:
倪卓1; 杨莎1; 吴耿峰1; 潘田光1; 刘学2; 任英华2; 林佩芳1; 林泽宇1
1）深圳大学化学与环境工程学院，广东深圳518060
2）深圳市第六人民医院口腔科，广东深圳 518067
Author(s):
Ni Zhuo1;  Yang Sha1;  Wu Gengfeng1;  Pan Tianguang1;  Liu Xue2;  Ren Yinghua2;  Lin Peifang1;  and Lin Zeyu1
1) College of Chemistry and Environmental Engineering，Shenzhen University, Shenzhen 518060, Guangdong Province, P.R.China
2) Department of Stomatology, The Sixth People’s Hospital of Shenzhen, Shenzhen 518067, P.R.China
关键词:
生物材料; 复合材料; 聚醚砜; 羟基磷灰石; 热稳定性; 分解动力学; 细胞毒性
Keywords:
biological materials;  composite materials;  polyether sulfone;  hydroxyapatite;  thermal stability;  decomposition kinetics;  cytotoxicity
分类号:
TB 332
DOI:
10.3724/SP.J.1249.2017.03313
文献标志码:
A
摘要:
采用溶解超声方法制备聚醚砜(polyethersulfone, PES)-羟基磷灰石（hydroxyapatite, HA）生物复合材料．红外光谱显示该复合材料主要为物理结合；热重分析研究发现，该组复合材料的热稳定性随HA质量分数的增加而增加，热分解反应级数均为1；细胞毒性测试发现，该组材料毒性级别均为Ⅰ级，对MG-63细胞无毒．加入HA的PES能够使细胞在复合材料中相对增值率增大，改善细胞生物相容性；荧光倒置显微镜观察发现，细胞在材料浸提液中生长良好，已贴壁的细胞形态为梭形或多角形，折光性强，存在明显的细胞增殖．
Abstract:
Polyethersulfone-hydroxyapatite (PES-HA) biocomposites were prepared by dissolving ultrasonic method. Infrared spectroscopy shows that the composites are mainly composed by physical bonding. The thermo gravimetric analysis indicates that the thermal stability of the composites increases with the increase of HA content and the thermal decomposition reaction order is about 1. Cytotoxicity test shows that the toxicity level of the material is gradeⅠ, and the composites have no toxicity to MG-63 cells. The addition of HA into PES results in a relative increase in the growth rate of cells for the composites, thus improving the cell biocompatibility. The cells grow well in the material extract, the adherent cells are spindle or polygonal, with strong refraction and obvious cell proliferation.

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备注/Memo

备注/Memo:
Received：2016-12-29；Accepted：2017-03-07
Foundation：National Natural Science Foundation of China (51378315); Shenzhen Science and Technology Research Foundation (JCYJ20140411094009912)
Corresponding author：Professor Ni Zhuo. E-mail: royzhuoni@hotmail.com
Citation：Ni Zhuo, Yang Sha, Wu Gengfeng, et al. Thermal stability and biotoxicity of PES-HA biocomposites［J］. Journal of Shenzhen University Science and Engineering, 2017, 34(3): 313-318.（in Chinese）
基金项目：国家自然科学基金资助项目(51378315)；深圳市科技计划资助项目(JCYJ20140411094009912)
作者简介：倪卓（1963—），男，深圳大学教授、博士生导师. 研究方向：生物材料和功能材料. E-mail：royzhuoni@hotmail.com
引文：倪卓，杨莎，吴耿峰，等.PES-HA生物复合材料的热稳定性和生物毒性［J］. 深圳大学学报理工版，2017，34(3)：313-318.
更新日期/Last Update: 2017-04-20