[1]屈军乐,陈丹妮,杨建军,等.二次谐波成像及其在生物医学中的应用[J].深圳大学学报理工版,2006,23(1):1-9.
 QU Jun-le,CHEN Dan-ni,YANG Jian-jun,et al. Second harmonic generation imaging and its applications in biomedicine[J].Journal of Shenzhen University Science and Engineering,2006,23(1):1-9.
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二次谐波成像及其在生物医学中的应用()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第23卷
期数:
2006年1期
页码:
1-9
栏目:
电子光学与信息工程
出版日期:
2006-01-30

文章信息/Info

Title:
 Second harmonic generation imaging and its applications in biomedicine
文章编号:
1000-2618(2006)01—0001—09
作者:
屈军乐1陈丹妮1杨建军2许改霞1林子扬1刘立新1牛憨笨1
1)深圳大学光电子学研究所,深圳518060
2)南开大学现代光学研究所,天津300071
Author(s):
QU Jun-le1CHEN Dan-ni1YANG Jian-jun2XU Gai-xia1LIN Zi-yang1LIU Li-xin1and NIU Han-ben1

1)Institute of Optoelectronics Shenzhen University ,Shenzhen 518060 , P.R.China

2)Institute of Modern Optics Nankai University ,Tianjin 300071, P.R. China

关键词:
二次谐波非线性光学生物组织显微成像早期诊断高分辨率活体成像
Keywords:
second harmonic generationnonlinear optical imagingbiological tissuemicroscopyearly diagnosishigh resolutionin vivo
分类号:
O 43;Q 6
文献标志码:
A
摘要:
二次谐波成像是近年发展起来的一种三维光学成像技术,具有非线性光学成像所特有的高空间分辨率和高成像深度,可避免双光子荧光成像中的荧光漂白效应,是一种理想的非侵入生物活体成像方法.生物组织的病变往往会引起微观结构的变化,而二次谐波信号对组织的结构对称性变化高度敏感,因此二次谐波成像对于某些疾病的早期诊断或术后治疗监测,具有很好的生物医学应用前景.介绍二次谐波成像的发展现状,生物组织中二次谐波信号的产生机理,二次谐波成像的实现手段及其在生物医学领域的应用.
Abstract:
Second haHllonic generation imaging(SHGI) is an emerging 3?D optical imaging modality in biomedicine. Because of its inherent nonlinear mechanism,SHGI has the unique advantages of high spatial resolution,large penetration depth and non—photobleaching,and is accepted as one of the promising and non—invasive biomedical imaging modalities. Pathological changes in biological tissues usually cause changes in their microstructure. Since the second harmonic generation(SHG) signal is highly sensitive to the symmetry change of the microstructure,SHGI can be used fbr the early diagnosis of diseases and the monitoring of aftertreatment in clinics.This paper provides an ovenriew of SHGI technology,signal mechanism in biological tissues,and the implementation and applications of SHGI in biomedicine.

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更新日期/Last Update: 2015-09-25