[1]朱颖,沈圆圆,陈昕,等.大鼠肝纤维化分期的流变特性分析[J].深圳大学学报理工版,2013,30(No.2(111-220)):216-220.[doi:10.3724/SP.J.1249.2013.02216]
　Zhu Ying,Shen Yuanyuan,Chen Xin,et al.Rheological properties analysis of rats liver in fibrosis stages[J].Journal of Shenzhen University Science and Engineering,2013,30(No.2(111-220)):216-220.[doi:10.3724/SP.J.1249.2013.02216]
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大鼠肝纤维化分期的流变特性分析()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第30卷
期数:
2013年No.2(111-220)
页码:
216-220
栏目:
生物工程
出版日期:
2013-03-18

文章信息/Info

Title:
Rheological properties analysis of rats liver in fibrosis stages
作者:
朱颖; 沈圆圆; 陈昕; 林浩铭; 汪天富; 陈思平
医学超声关键技术国家地方联合工程实验室，广东省生物医学信息检测与超声成像重点实验室，深圳大学医学院, 深圳 518060
Author(s):
Zhu Ying;  Shen Yuanyuan;  Chen Xin;  Lin Haoming;  Wang Tianfu;  and Chen Siping
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical
Measurements and Ultrasound Imaging, School of Medicine, Shenzhen University, Shenzhen 518060, P.R. China
关键词:
生物力学; 肝纤维化; 流变力学; Zener模型; Voigt模型; 弹性系数; 黏性系数; 剪切模量; 大鼠肝脏
Keywords:
biological mechanics;  liver fibrosis;  rheological mechanics;  Zener model;  Voigt model;  elasticity;  viscosity;  shear modulus;  rat liver
分类号:
R 318.01；Q 66； R 333.4
DOI:
10.3724/SP.J.1249.2013.02216
文献标志码:
A
摘要:
指出肝脏纤维化会导致生物组织的力学属性发生改变，按照纤维化分期对大鼠肝脏组织进行流变力学实验．用Zener和Voigt两类黏弹性模型解释实验得到的剪切模量．结果表明，Zener模型比Voigt模型能更好地描述大鼠肝纤维化各分期的组织流变特性，尤其是Zener模型的弹性系数E2从F1到F2期有显著改变．研究还发现E2值可视为区分纤维化轻度（F1期）以下、中度（F2期）以上的分水岭，这一发现为肝脏黏弹性与纤维化分级的理论研究提供了新思路．
Abstract:
The process of liver fibrosis changes rheological properties of tissue. This study characterized and compared liver fibrosis stages from F0 to F4 of rats using rheological mechanics experiments. Two viscoelasticity models—Voigt model and Zener model were applied to explain the experimental data. The experiments results indicate that Zener model is preferred to Voigt model for describing rheological properties of liver fibrosis each stage of rats, especially the order of magnitudes of the elasticity E2 of Zener model declining significantly from stage F1 to F2. The study indicate that the elasticity E2 can be regarded as a watershed of mild fibrosis(≤F1)and moderate fibrosis(≥F2), which provides a new idea for the research of the relationship of liver viscoelasticity and fibrosis grading.

参考文献/References:

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备注/Memo

备注/Memo:
Received：2012-09-14；Accepted：2013-03-06
Foundation：National Natural Science Foundation of China(61031003, 81101171)
Corresponding author：Professor CHEN Siping. E-mail: chensiping@szu.edu.cn
Citation：Zhu Ying, Shen Yuanyuan, Chen Xin, et al. Rheological properties analysis of rats liver in fibrosis stages［J］. Journal of Shenzhen University Science and Engineering, 2013, 30(2): 216-220.（in Chinese）

基金项目：国家自然科学基金资助项目（61031003，81101171）
作者简介：朱颖（1980-），女（汉族），江西省彭泽县人，深圳大学博士研究生. E-mail：jgwenzying@yahoo.com.cn
引文：朱颖，沈圆圆，陈昕，等. 大鼠肝纤维化分期的流变特性分析［J］. 深圳大学学报理工版，2013，30（2）：216-220.

更新日期/Last Update: 2013-03-21