[1]许改霞,杨坚泰,Roy Indrajit,等.纳米颗粒在穿透血脑屏障研究中的应用[J].深圳大学学报理工版,2009,26(1):1-8.
 XU Gai-xia,YONG Ken-Tye,ROY Indrajit,et al.The application of nanoparticle in BBB transmigration[J].Journal of Shenzhen University Science and Engineering,2009,26(1):1-8.
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纳米颗粒在穿透血脑屏障研究中的应用()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第26卷
期数:
2009年1期
页码:
1-8
栏目:
光学工程
出版日期:
2009-01-30

文章信息/Info

Title:
The application of nanoparticle in BBB transmigration
文章编号:
1000-2618(2009)01-0001-08
作者:
许改霞1 杨坚泰2 Roy Indrajit2 屈军乐1 陈丹妮1 王晓梅3 Prasad N. Paras2 牛憨笨1
1)深圳大学光电子学研究所, 教育部光电子器件与系统重点实验室, 广东省光电子器件与系统重点实验室,深圳市生物医学工程重点实验室,深圳5 1 8060
2)美国纽约州立大学水牛城分校激光、光子学与生物光子学研究所,水牛城,美国,14260-3000
3)深圳大学生命科学学院, 深圳518060
Author(s):
XU Gai-xia1YONG Ken-Tye2ROY Indrajit2QU Jun-le1CHEN Dan-ni1WANG Xiao-mei3PRASAD N.Paras2 and Hanben NIU1
1)Institute of Optoelectronics,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education,Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province,Key Laboratory of Biomedical Engineering of Shenzhen,Shenzhen University,Shenzhen 518060,P.R.China
2)Institute for Lasers,Photonics and Biophotonics,State University of New York at Buffalo,Buffalo 14260-3000,USA
3)College of Life Science,Shenzhen University,Shenzhen 518060,P.R.China
关键词:
纳米颗粒血脑屏障纳米药物载体量子棒磁性纳米粒金纳米颗粒
Keywords:
nanoparticleblood-brain barrierquantum rodsmagnetic nanoparticlegold nanoparticle
分类号:
043; Q6
文献标志码:
A
摘要:
阐述纳米颗粒在血脑屏障相关的脑部疾病研究中的进展,分析应用在血脑屏障研究中的几类纳米颗粒,分别对治疗、诊断/追踪及多功能纳米颗粒的材料组成、功能特点和应用现状进行许这.介绍在靶向纳米颗粒穿透血脑屏障可视化研究中的成果,指出纳米颗粒在血脑屏障研究中的发展方向.
Abstract:
Recently,the advancements in nanotechnology and better understanding of the BBB physiology have promoted the use of nanoparticles for targeted delivery across the BBB for therapy of neuronal diseases/disorders.This review summarizes the applications of several classes of novel nanoparticles to blood-brain barrier (BBB) for therapy, diagnosis, dynamic imaging, and multifunctional mode, including the materials, functions characteristics, as well as their current research status. Our recent progress on visualization of targeted nanoparticle delivery across BBB is also introduced.Finally,the research trend of using nanoparticles for transmigration across BBB and treatment of brain diseases has been highlighted.

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备注/Memo

备注/Memo:
收稿日期:2008-09-11;修回日期:2008-11-25
基金项目:国家自然科学基金专项基金资助项目(60627003);广东省高等学校创新团队资助项目(OGCXTD009);广东省自然科学基金资助项目(2008078);深港创新圈专项资助计划(CXQ2008043)
作者简介:许改霞(1977-),女(汉族),内蒙古自治区巴彦淖尔市人,深圳大学副研究员、博士.E-mail
xugaixia@szu.edu.cn
更新日期/Last Update: 2009-02-06