[1]李步洪,余松林,谢树森,等.α-(8-喹啉氧基)单取代酞菁锌的单态氧量子产率[J].深圳大学学报理工版,2008,25(4):387-391.
 LI Bu-hong,YU Song-lin,XIE Shu-sen,et al.Singlet oxygen quantum yield of α-(8-quinolinoxy)zinc phthalocyanine[J].Journal of Shenzhen University Science and Engineering,2008,25(4):387-391.
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α-(8-喹啉氧基)单取代酞菁锌的单态氧量子产率()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第25卷
期数:
2008年4期
页码:
387-391
栏目:
生物医学工程
出版日期:
2008-10-31

文章信息/Info

Title:
Singlet oxygen quantum yield of α-(8-quinolinoxy)zinc phthalocyanine
文章编号:
1000-2618(2008)04-0387-05
作者:
李步洪1余松林1谢树森1薛金萍2
1)福建师范大学医学光电科学与技术教育部重点实验室,福州 350007
2)福州大学化学化工学院功能材料研究所,福州 350002
Author(s):
LI Bu-hong1YU Song-lin1XIE Shu-sen1and XUE Jin-ping2
)Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education,Fujian Normal University,Fujian 350007,P.R.China
2)Institute of Functional Materials,College of Chemistry and Chemical Engineering,Fuzhou University,Fujian 350007,P.R.China
关键词:
α-(8-喹啉氧基)单取代酞菁锌单态氧近红外发光量子产率光动力学疗法
Keywords:
α-(8-quinolinoxy) zinc phthalocyaninesinglet oxygennear-infrared luminescencequantum yieldphotodynamic therapy
分类号:
O 657.3
文献标志码:
A
摘要:
研究新型光敏剂α-(8-喹啉氧基)单取代酞菁锌在N,N-二甲基甲酰胺(N,N-dimethylformamide,DMF)中1O2的近红外发光光谱特性,以玫瑰红作为参考标样,测定其1O2量子产率.结果表明,α-(8-喹啉氧基)单取代酞菁锌在DMF中的最大吸收峰位于675 nm,摩尔消光系数为1.86×105 mol-1cm-11O2近红外发光的最大发射峰位于1 280 nm,量子产率为0.60±0.02.与现有酞菁金属配合物相比,α-(8-喹啉氧基)单取代酞菁锌是一种具有开发前景的新型光动力学疗法光敏剂.
Abstract:
Singlet oxygen (1O2) is widely considered to be the major cytotoxic agent for photodynamic therapy (PDT),and the 1O2 quantum yield,one of the most important parameters,is characterizing efficiency of the potential photosensitizers.Measurement of 1O2 quantum yield for the novel photosensitizer of α-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO)PcZn) in air-saturated dimethylformamide solutions was achieved by the direct measurement of their near-infrared luminescence.The main Q band for α-(8-QLO)PcZn peaks at 675 nm,and its molar extinction coefficient is 1.86×105 mol-1cm-1.The maximal 1O2 luminescence occurs at 1 280 nm,and the 1O2 quantum yield of α-(8-QLO)PcZn was determined to be 0.60±0.02.These results indicate that α-(8-QLO)PcZn is a promising photosensitizer for PDT applications.

参考文献/References:

[1]Weishaupt K R,Gomer C J,Dougherty T J. 单态氧是光抑制小鼠肿瘤的主要毒性物质[J]. 肿瘤研究,1976,36(7):2326-2329(英文版).
[2]Wilson B C,Patterson M S.光动力学疗法中的物理学、生物物理学和技术[J].医学和生物学中的物理学,2008,53(9):R61-R109(英文版).
[3]Juzeniene A,Peng Q,Moan J.光动力学疗法和荧光诊断的发展里程牌[J].光化学和光生物,2007,6(12):1234-1245(英文版).
[4]Wainwright M.光动力学疗法:新型光敏剂的研究进展[J].医药化学抗癌药剂,2008,8(3):280-291(英文版).
[5]Ogunsipe A,Nyokong T.取代基和溶剂对酞菁锌及其质子化衍生物的光化学特性影响[J].分子结构杂志,2004,689(1/2):89-97(英文版).
[6]薛金萍,刘宏,范长安,等.四-α-(2-甲基-8喹啉氧基)酞菁金属配合物的合成、表征及光敏活性研究[J].化学学报,2007,65(16):1605-1611.
[7]Tebello N.取代基对金属酞菁类光敏剂的光化学和光物理特性影响[J].配位化学评论, 2007,251(13/14):1707-1722(英文版).
[8]Yamamoto J,Yamamoto S,Hirano T,等. 监测单态氧可用于预测胶质瘤的光动力学效应[J]. 临床肿瘤研究,2006,12(23):7132-7139(英文版).
[9]李步洪,Jarvi M T,Moriyama E H,等.光动力学疗法的单态氧剂量评估[J].中国科学G辑,2007,37(S1):153-160.
[10]WEI Yan-chun,XING Da,LUO Shi-ming,等. 通过利用延迟化学发光在体监测单态氧来预测光动力学治疗的疗效[J].生物医学光学杂志,2008,13(2):024023(英文版).
[11]LI Bu-hong,LIN Li-sheng,LIN Hui-yun,等.卟啉类光敏剂的单态氧量子产率[J].光学保健科学创新杂志,2008,1(1):141-149(英文版).
[12]Redmond R W,Gamlin J N.生物学相关分子物质的单态氧产率[J].光化学和光生物,1999,70(4),391-475(英文版).
[13]Atilla D,Durmu M,Gürek A G,等.聚乙稀取代基酞菁锌的合成、光物理和光化学特性[J].道尔顿汇刊,2007(12):1235-1243(英文版).

[1]Weishaupt K R,Gomer C J,Dougherty T J. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor[J].Cancer Research,1976,36(7):2326-2329.
[2]Wilson B C,Patterson M S.The physics,biophysics and technology of photodynamic therapy[J].Physics in Medicine and Biology,2008,53(9):R61-109.
[3]Juzeniene A,Peng Q,Moan J.Milestones in the development of photodynamic therapy and fluorescence diagnosis[J].Photochemical and Photobiological Science,2007,6(12):1234-1245.
[4]Wainwright M.Photodynamic therapy:the development of new photosensitizers[J].Anticancer Agents Med Chem,2008,8(3):280-291.
[5]Ogunsipe A,Nyokong T.Effects of substituents and solvents on the photochemical properties of zinc phthalocyanine complexes and their protonated derivatives[J].Journal of Molecular Structure,2004,689(1/2):89-97.
[6]XUE JIN-ping,LIU HONG,FAN CHANG-An,et al.Synthesis,Characterization and photosensitivity study of tetrakis-α-(2-methyl-8-quinolinoxy)metallophthalocyanines[J].Acta Chimica Sinica,2007,65(16):1605-1611 (in Chinese).
[7]Tebello N.Effects of substituents on the photochemical and photophysicalpropertiesofmaingroupmetal phthalocyanines[J].Coordination Chemistry Reviews,2007,251(13/14):1707-1722.
[8]Yamamoto J,Yamamoto S,Hirano T,et al. Monitoring of singlet oxygen is useful for predicting the photodynamic effects in the treatment for experimental glioma[J].Clinical Cancer Research,2006,12(23):7132-7139.
[9]LI BU-hong,Jarvi M T,Moriyama E H,et al.Singlet oxygen dosimetry for Photodynamic therapy[J].Science in China Series G,2007,37(S1):153-160 (in Chinese).
[10]WEI Yan-chun,XING Da,LUO Shi-ming,et al. Monitoring singlet oxygen in situ with delayed chemiluminescence to deduce the effect of photodynamic therapy[J].Journal of biomedical optics,2008,13(2):024023.
[11]LI Bu-hong,LIN Li-sheng,LIN Hui-yun,et al.Singlet oxygen quantum yields of porphyrin-based photosensitizers for photodynamic therapy[J].Journal of Innovation in Optical Health Science,2008,1(1):141-149.
[12]Redmond R W,Gamlin J N.A compilation of singlet oxygen yields from biologically relevant molecules[J].Photochem Photobiol,1999,70(4):391-475.
[13]Atilla D,Durmu M,Gürek A G,et al.Synthesis,photophysical and photochemical properties of poly(oxyethylene)-substituted zinc phthalocyanines[J].Dalton Transcatums,2007(12):1235-1243.

备注/Memo

备注/Memo:
收稿日期:2008-06-01
基金项目:福建省自然科学基金重点资助项目(2008J0001);福建省教育厅科技资助项目(JA08031);福建省科技计划重点资助项目(2006Y0020)
作者简介:李步洪(1973-),男(汉族),福建省福州市人,福建师范大学副教授、博士.E-mail:bhli@fjnu.edu.cn
*本文为2008第3届国际生物医学光学方法高级研讨会宣读论文
更新日期/Last Update: 2008-11-26