[1]吕维忠,刘　波,韦少慧,等.微波合成1-对羟基苄基-2-对羟基苯基苯并咪唑[J].深圳大学学报理工版,2007,24(4):432-435.
　LU Wei-zhong,LIU Bo,WEI Shao-hui,et al.Synthesis of 1-(p-hydroxybenzyl)-2-(p-hydroxyphenzyl)-benzimidazole under microwave irradiation[J].Journal of Shenzhen University Science and Engineering,2007,24(4):432-435.
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微波合成1-对羟基苄基-2-对羟基苯基苯并咪唑()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第24卷
期数:
2007年4期
页码:
432-435
栏目:
化学与化工
出版日期:
2007-10-30

文章信息/Info

Title:
Synthesis of 1-(p-hydroxybenzyl)-2-(p-hydroxyphenzyl)-benzimidazole under microwave irradiation
文章编号:
1000-2618(2007)04-0432-04
作者:
吕维忠; 刘　波; 韦少慧; 吴奕光; 刘剑洪
深圳大学化学与化工学院，深圳 518060
Author(s):
LU Wei-zhong; LIU Bo; WEI Shao-hui; WU Yi-guang; and LIU Jian-hong
College of Chemistry and Chemical Engineering，Shenzhen University，Shenzhen 518060，P． R． China
关键词:
微波辐射; 邻苯二胺; 对羟基苯甲醛; 苯并咪唑
Keywords:
microwave irradiation; o-phenylenediamine; p-hydroxybenaldehyde; benzimidazole
分类号:
O 626.25
文献标志码:
A
摘要:
在微波辐射下，用乙醇作溶剂，以邻苯二胺和对羟基苯甲醛为原料，合成了对1-羟基苄基-2-对羟基苯基苯并咪唑．利用正交法优化微波促进该反应的工艺条件，优化工艺参数，选n(对羟基苯甲醛)：n(邻苯二胺)为2．3∶1．0，微波辐射温度为78℃，微波辐射时间为60 min，产率达69．7％．用IR、1HNMR和13CNMR对产物进行了表征．
Abstract:
1-(p-hydroxybenzyl)-2-(p-hydroxyphenzyl)-benzimidazole was synthesized by the reaction of o-phenylenediamine with p-hydroxybenaldehyde．The reaction was accelerated by microwave irradiation with ethyl alcohol as solvent．The method of orthogonal experiment optimized synthesis factors which affect the reaction．The reaction parameters are n(p-hydroxybenaldehyde):n(o-phenylenediamine)=2．3∶1．0， and the temperature of microwave irradiation 78℃，the time of microwave irradiation 60min．The highest yield of the title compound was 69.7%．The samples synthesized were characterized by melting point determination，IR spectrogram，1HNMR spectra and 13CNMR spectra．

参考文献/References:

［1］Shou-Yuan Lin，Yuko Isome，Ethan Stewart，等． 微波辅助一步法高效合成苯并咪唑［J］．四面体通报， 2006，47：2883-2886(英文版)．
［2］吕维忠，刘　波，韦少慧． 苯并咪唑-2-硫的无溶剂微波合成［J］．深圳大学学报理工版，2005，22(4)：345-348．
［3］Varma R S． 微波无溶剂合成杂环化合物 ［J］．杂环化学杂志，1999，36(1)：565-571(英文版)．
［4］杨红伟，岳　凡，封　顺，等． 苯并咪唑类化合物一步法合成及表征［J］． 有机化学， 2004，24(7)：792-796．
［1］Shou-Yuan Lin，Yuko Isome，Ethan Stewart，et al．Microwave-assisted one step high-throughput synthesis of benzimidazoles［J］．Tetrahedron Letters，2006，47：2883-2886．
［2］LU Wei-zhong，LIU Bo，WEI Shao-hui． Solvent-free synthesis of 2-sulfur Benzimidaozole under microcave irradiation［J］．Journal of Shenzhen University Science and Engineering，2005，22(4)：345-348(in Chinese)．
［3］Varma R S．Solvent-free synthesis of heterocyclic compounds using microwaves［J］．J Heterocycl Chem，1999，36(1)： 565-571．
［4］YANG Hong-wei，YUE Fan，FENG Shun，et al．One-step synthesis and characteristics of benzimidazole derivatives［J］． Chinese Journal of Organic Chemstry，2004，24(7)：792-796(in Chinese)．

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备注/Memo

备注/Memo:
收稿日期：2007-03-01；修回日期：2007-06-28
作者简介：吕维忠(1971-)，男(汉族)，江西省兴国县人，深圳大学副教授、博士．E-mail：weizhonglv@163．com
通讯作者：刘剑洪(1964-)，男(汉族)，深圳大学教授、博士生导师．E-mail：liujh@szu．edu．cn
更新日期/Last Update: 2007-12-05