[1]刘 波,吕维忠,吴奕光,等.2-硝基苯基苯并咪唑衍生物微波合成[J].深圳大学学报理工版,2007,24(3):309-312.
 LIU Bo,LU Wei-zhong,WU Yi-guang,et al.Microwave synthesis of 2-nitrophenzyl-benzimidazole derivatives[J].Journal of Shenzhen University Science and Engineering,2007,24(3):309-312.
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2-硝基苯基苯并咪唑衍生物微波合成()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第24卷
期数:
2007年3期
页码:
309-312
栏目:
化学与化工
出版日期:
2007-07-30

文章信息/Info

Title:
Microwave synthesis of 2-nitrophenzyl-benzimidazole derivatives
文章编号:
1000-2618(2007)03-0309-04
作者:
刘 波吕维忠吴奕光韦少慧 刘剑洪
深圳大学化学与化工学院,深圳 518060
Author(s):
LIU BoLU Wei-zhong WU Yi-guangWEI Shao-hui and? LIU Jian-hong
College of Chemistry and Chemistry Engineering,Shenzhen University,Shenzhen 518060,P. R. China
关键词:
微波合成苯并咪唑衍生物正交实验有机合成
Keywords:
microwave irradiationbenzimidazole derivativesorthogonal experimentorganic synthesis
分类号:
O 626.25
文献标志码:
A
摘要:
在微波辐射下,以乙醇为溶剂,以邻苯二胺和硝基苯甲醛为原料,合成3种2-硝基苯基苯并咪唑.利用正交法优化微波促进该反应工艺条件,优化工艺参数为n(邻苯二胺)∶n(硝基苯甲醛)=1.2∶1.0,微波辐射温度为58℃,微波辐射20 min.在优化条件下产率达81.2%,产物经熔点测试,采用IR和1HNMR进行表征确认.
Abstract:
2-nitrophenzyl-benzimidazole was synthesized by the reaction of o-phenylenediamine with nitro-benaldehyde which was accelerated by microwave irradiation and ethyl alcohol as solvent. The method of orthogonal experiment was used to optimize synthesis factors which affect the reaction:n(o-phenylenediamine)∶n(nitro benaldehyde)=1.2∶1.0,and the temperature of microwave irradiation 58℃,the time of microwave irradiation 20 min. Under the optimal condition,the highest yield of the title compound was a bout 81.2%. The samples synthesized were characterized by melting point determination,IR spectrogram,1HNMR spectra.

参考文献/References:

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[1]BEI Feng-li,CHEN Hai-qun,YANG Xu-jie,et al. Synthesis,crystal stucture and quantum chemical calculation of benzimidazole derivatives [J] . Chinese Journal of Organic Chemistry,2004,24(3):300-305(in Chinese).
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相似文献/References:

[1]逄艳,吕维忠,王芳,等.1,3-双(2′-苯并咪唑基)苯的微波合成及表征[J].深圳大学学报理工版,2009,26(2):193.
 PANG Yan,LU Wei-zhong,WANG Fang,et al.Synthesis and characterization of 1,3-di(2′-benzimidazole)benzene under microwave irradiation[J].Journal of Shenzhen University Science and Engineering,2009,26(3):193.

更新日期/Last Update: 2007-12-07