[1]蒋灵芝,熊平.养寿丹对AD模型大鼠脑内β-APP蛋白表达的影响[J].深圳大学学报理工版,2006,23(4):368-372.
 JIANG L ing-zhi and XIONG P ing.Effect of Yangshoudan on the expression of β-APP in rat’s brain with Alzhemier’s disease [J].Journal of Shenzhen University Science and Engineering,2006,23(4):368-372.
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养寿丹对AD模型大鼠脑内β-APP蛋白表达的影响()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第23卷
期数:
2006年4期
页码:
368-372
栏目:
土木建筑工程
出版日期:
2006-10-30

文章信息/Info

Title:
Effect of Yangshoudan on the expression of β-APP in rat’s brain with Alzhemier’s disease
文章编号:
1000-2618(2006)04-0368-05
作者:
蒋灵芝1熊平2
1)深圳大学生命科学学院,深圳518060
2)华南农业大学资源环境学院,广州510642
Author(s):
JIANG L ing-zhi1 and XIONG P ing2
1)College o f Life Sciences Shenzhen University Shenzhen 518060 P. R. China
2)College of Resources and Environment South China Agricultural University Guangzhou 510642P. R. China
关键词:
养寿丹中药脑组织β-APP 蛋白AD动物模型大鼠
Keywords:
Yangshoudan traditional Chinese drug tissue of rat brainβ -amyloid peptide precursorAD animal model rat
分类号:
R 285.5
文献标志码:
A
摘要:
大鼠腹腔注射; P-半乳糖,并同时注射鹅膏蕈胺酸(IBO)于双侧脑Meynert基底核建立AD动物模型,石杉碱甲作阳性药物对照组,用免疫组织化学染色法检测脑内β-APP蛋白的表达水平.手术阳性对照组、中药大剂量组和中药小剂量组大鼠脑内β-APP表达水平均低于AD模型组(P﹤0.05).中药剂量越大,β-APP蛋白表达越低.实验结果证明养寿丹可以降低脑内β-APP表达水平.
Abstract:
This study is carried out to find out the effect of Yangshoudan on the expression of β -APP in rat’s brain with Alzheimer’s disease (AD). The AD animal model was achieved by intraperitoneal injection of D-galactose and injection with ibotenic acid (IBO) in both sides of the basal Ganglia of meynert in rat brain. Huperzine A was used as positive pharmaceutic control. The expression of β -APP in the brain was detected by immunohistochemical staining.It showed that the expression levels of β -APP in the surgery group, high-dose-yangshoudan treated group and low-dose-yangshoudan treated group w e re distinctly lower than that in the AD model group. And higher dose of Yangshoudan results in lower expression of β -APP. It indicated that Yangshoudan could down regulate the expression of β -APP in the brain.
更新日期/Last Update: 2015-06-26