[1]吕维忠,刘波,韦少慧.苯并咪唑-2-硫的无溶剂微波合成[J].深圳大学学报理工版,2005,22(4):345-348.
 LU Wei-zhong,LIU Bo,WEI Shao-hui.Solvent-free synthesis of 2-sulfur Benzimidaozole under microware irradiation[J].Journal of Shenzhen University Science and Engineering,2005,22(4):345-348.
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苯并咪唑-2-硫的无溶剂微波合成()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第22卷
期数:
2005年4期
页码:
345-348
栏目:
生命科学
出版日期:
2005-10-30

文章信息/Info

Title:
Solvent-free synthesis of 2-sulfur Benzimidaozole under microware irradiation
文章编号:
1000-2618(2005)04-0345-04
作者:
吕维忠刘波韦少慧
深圳大学理学院,深圳518060
Author(s):
LU Wei-zhongLIU BoWEI Shao-hui
College of Science Shenzhen University Shenzhen 518060 P. R. China
关键词:
微波辐射无溶剂苯并咪唑-2-硫微波化学
Keywords:
microwave irradiationsolvent-free reaction2-sulfur Benzimidaozolemicrowave chemistry
分类号:
TQ 252. 3
文献标志码:
A
摘要:
以多聚磷酸(PPA)作催化剂,在无溶剂微波照射下,用邻苯二胺与硫脲合成苯并咪唑-2-硫,为合成目标产物提供了一种新方法,与常规合成法相比,反应时间由2~3 h缩短至6~10 min.正交试验结果表明影响因素的影响顺序为:微波功率>催化剂用量>原料配比>照射时间;最优化工艺条件是:邻苯二胺与硫脲的摩尔比为1:2,微波功率为126 W,微波照射时间为6 min,催化剂用量为7 mL. 通过数字熔点仪、红外光谱仪、核磁共振谱仪对合成的产物进行表征.
Abstract:
2-sulfur benzimidaozole was synthesized by the reaction o-phenylendiamine with thiourea using polyphosphoric acid(PPA) as a catalyst under solvenl-free conditions. This method is simple and inexpensive. The reaction time is shortened to 6-10 min and is twenty times faster than traditional methods. The results of orthogonal tests show the effect factor order to be as follows: microwave power>the concentration of catalyst>ratio of raw materials>radiation time. The optimum reaction conditions are: mol ratio of o-phenylendiamine and thiourea is 1:2,microwave power is 126w,reaction time is 6 min,and PPA acid is 7 mL. The structure of the product is characterized by melting point determination,IR NMR et al.

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更新日期/Last Update: 2015-10-16