[1]张雪利,洪伟良,刘剑洪,等.班布特罗的合成工艺改进[J].深圳大学学报理工版,2005,22(3):269-271.
　ZHANG Xue-li,HONG Wei-liang,LIU Jian-hong,et al.Improvement of synthesis process for Bambutarol[J].Journal of Shenzhen University Science and Engineering,2005,22(3):269-271.
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班布特罗的合成工艺改进()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第22卷
期数:
2005年3期
页码:
269-271
栏目:
化学与化工
出版日期:
2005-07-30

文章信息/Info

Title:
Improvement of synthesis process for Bambutarol
文章编号:
1000-2618(2005)03-0269-03
作者:
张雪利; 洪伟良; 刘剑洪; 张培新; 罗仲宽; 周晓明
深圳大学师范学院，深圳518060
Author(s):
ZHANG Xue-li; HONG Wei-liang; LIU Jian-hong; ZHANG Pei-xin; LUO Zhong-kuan; ZHOU Xiao-ming
Normal College Shenzhen University Shenzhen 518060 P. R. China
关键词:
班布特罗; 溴代; 胺化; β2受体激动剂; 合成工艺
Keywords:
Bambuterol; bromination; amination;  β2-agonist; technical improvement
分类号:
O 621. 3
文献标志码:
A
摘要:
针对目前国内班布特罗合成收率较低的情况，提出一条新的合成路线.以3, 5一二羟基苯乙酮为起始原料，经酯化一溴代—胺化—还原4步反应合成了班布特罗，各步反应简单，条件温和，总收率60. 80%，是迄今为止成本最低的工艺之一，为工业生产提供了较佳的合成路线.
Abstract:
To improve the synthesis of Bambuterol hydrochloride，Bambuterol hydrochloride was synthesized from 3, 5-dihydroxyacetophenone via four steps，esterification，bromination，amination and reduction.The overall yield of 60. 80% was two times higher than that of reported previously. The reaction conditions were mild and the processes were straight forward. A better industrial way for synthesis of Bambuterol hydrochloride is obtained.

相似文献/References:

[1]张雪利,刘剑洪,洪伟 良,等.叔丁喘宁的合成工艺改进[J].深圳大学学报理工版,2005,22(2):105.
　ZHANG XUE-li,LIU Jian-hong,HONG Wei-liang,et al.Improvement of Terbutaline sulphate synthesis[J].Journal of Shenzhen University Science and Engineering,2005,22(3):105.

更新日期/Last Update: 2015-10-16