[1]何晓阳,殷恭宽.温湿度对VC片剂变色反应的影响[J].深圳大学学报理工版,1997,14(2-3):77-82.
　He Xiaoyang,Yin Gongkuan.Effects of Temperature and Humidity on Discoloration of Vitamin C Tablets[J].Journal of Shenzhen University Science and Engineering,1997,14(2-3):77-82.
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温湿度对VC片剂变色反应的影响()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第14卷
期数:
1997年2-3期
页码:
77-82
栏目:
电子与信息科学
出版日期:
1997-09-30

文章信息/Info

Title:
Effects of Temperature and Humidity on Discoloration of Vitamin C Tablets
作者:
何晓阳1; 殷恭宽2

1. 深圳大学应用化学系, 深圳 518060； 2.华西医科大学药学院，成都 610041

Author(s):
He Xiaoyang1;  Yin Gongkuan2

1. Dept. of Applied Chemistry Shenzhen University, Shenzhen 518060, P .R .China;
2.Faculty of Pharmacy The West China University of Medical Sciences, Chengdu 610041, P. R. China

分类号:
R 913; R 977.23
摘要:
报道了在密封避光条件下 ,采用恒温恒湿加速试验法,研究温度与湿度对VC 片剂变色反应动力学的影响.VC 片剂表面颜色变化用漫反射光谱监测, 在相对湿度(RH)低于临界相对湿度(CRH)时,表观变色反应速度常数 kc 与温度和相对湿度间具有定量关系:kc =k′exp(-Ea/ T)exp(m′RH),式中k′、m′为常数 ,表观变色反应活化能 Ea 为98 .36kJ·mol-1 .在相同实验温度、湿度范围,VC片剂表面反射率(R)与其溶液透光率(T0 )间亦存在定量关系:log(100/T0 -1)=L + log R ,式中 L 与 s 为常数。
Abstract:
The effect s of temperature and humidity on discoloration kinetics of Vitamin C tablets were studied by accelerated test under isothermal and constant humidity conditions . The changes of col - or of the Vitamin C tablet s were monitored by Diffuse Reflectance Spectroscopy ( DRS ). When relative humidity ( RH ) is less than the critical relative humidity ( CRH ), the apparent rate constant of discoloration of the Vitamin C tablets is k c = k ′ exp (- E a / T - 1 ) ex p ( m ′ RH ), w here k ′ and m ′ are constant s , and the activation eergy E a is 98 . 36kJ / mol . Under the same experiment al conditions ,it was found that the reflective ratio R of the Vitamin C tablets is related with the transparency T 0 of this tablets’ solution :log (100/ T0-1)=L +s log R ,where L and s are all constants .           
更新日期/Last Update: 2016-03-15