[1]张鹏鹏,高雪华,王青敏,等.角膜黏弹性定量测量评估胶原交联处理效果[J].深圳大学学报理工版,2017,34(No.4(331-440)):428-433.[doi:10.3724/SP.J.1249.2017.04428]
 Zhang Pengpeng,Gao Xuehua,Wang Qingmin,et al.Assessing the effect of collagen cross-linking by quantitative measurement of corneal viscoelasticity[J].Journal of Shenzhen University Science and Engineering,2017,34(No.4(331-440)):428-433.[doi:10.3724/SP.J.1249.2017.04428]
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角膜黏弹性定量测量评估胶原交联处理效果()
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《深圳大学学报理工版》[ISSN:1000-2618/CN:44-1401/N]

卷:
第34卷
期数:
2017年No.4(331-440)
页码:
428-433
栏目:
电子与信息科学
出版日期:
2017-07-10

文章信息/Info

Title:
Assessing the effect of collagen cross-linking by quantitative measurement of corneal viscoelasticity
文章编号:
201704014
作者:
张鹏鹏高雪华王青敏吕振张新宇
医学超声关键技术国家地方联合工程实验室, 广东省生物医学信息检测与超声成像重点实验室, 深圳大学医学部,深圳 518060
Author(s):
Zhang Pengpeng Gao Xuehua Wang Qingmin Lyu Zhen and Zhang Xinyu
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Health Science Center, Shenzhen University, Shenzhen 518060, P.R.China
关键词:
生物医学测量学医学超声超声弹性成像声辐射力角膜黏弹性胶原交联处理
Keywords:
biomedical measurement medical ultrasound ultrasound elastography acoustic radiation force cornea viscoelasticity collagen cross-linking
分类号:
R 318.01; R 445.1
DOI:
10.3724/SP.J.1249.2017.04428
文献标志码:
A
摘要:
建立基于VerasonicsTM Vantage256 超声开放系统的实验平台,用声辐射力激励角膜振动,通过快速平面波成像检测A0模式兰姆波的传播,根据兰姆波的频散特性估计牛眼角膜的剪切弹性模量和剪切黏性系数.通过对牛眼角膜进行离体实验研究,评估紫外线-核黄素角膜胶原交联术(corneal collagen cross-linking, CXL)中加入戊二醛和不同紫外线照射时间的影响.结果表明,加入质量分数为0.1%的戊二醛对角膜的硬化效果较未加入的更强.加入质量分数为0.1%的戊二醛的CXL处理组,紫外线照射5、10、30和60 min对应的杨氏模量比直接CXL处理组的弹性值分别增大了148.78%、335.68%、392.59%和250.47%.
Abstract:
This study establishes an experimental platform based on VerasonicsTM Vantage 256 ultrasonic open system, and uses the acoustic radiation force to excite the corneal vibration and uses plane wave imaging to detect A0 mode Lamb wave. The corneal shear elastic modulus and shear viscosity are estimated based on Lamb wave dispersion characteristics. In order to validate the effectiveness of this system, two kinds of CXL treatments are introduced to treat bovine corneas, and the effect of the treatment with different reagent and UV exposure duration are evaluated. The results show that the CXL with the addition of glutaraldehyde (0.1% mass concentration) in riboflavin solution induces significantly higher increase in elasticity in comparison with those without glutaraldehyde. The elasticity of the group with glutaraldehyde after 5, 10, 30 and 60 min UVA exposure increases by 148.78%、 335.68%, 392.59% and 250.47%, respectively, in comparison with the groups without glutaraldehyde.

参考文献/References:

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【中文责编:英子;英文责编:子兰】

备注/Memo

备注/Memo:
Received:2017-04-12;Accepted:2017-04-29
Foundation:National Natural Science Foundation of China(61101025,81570552);Shenzhen Basic Research Project(JCYJ20150625102427087)
Corresponding author:Associate professor Zhang Xinyu. E-mail: xyzhang9@szu.edu.cn
Citation:Zhang Pengpeng, Gao Xuehua, Wang Qingmin, et al. Assessing the effect of collagen cross-linking with quantitative measurement of corneal viscoelasticity [J]. Journal of Shenzhen University Science and Engineering, 2017, 34(4): 428-433.(in Chinese)
基金项目:国家自然科学基金资助项目(61101025,81570552);深圳市基础研究基金资助项目 (JCYJ20150625102427087)
作者简介:张鹏鹏(1991—),男,深圳大学硕士研究生.研究方向:医学超声.E-mail:ZhangPengpengSZ@163.com
引文:张鹏鹏,高雪华,王青敏,等.角膜黏弹性定量测量评估胶原交联处理效果[J]. 深圳大学学报理工版,2017,34(4):428-433.
更新日期/Last Update: 2017-06-26